Activation of coagulation factor VII during alimentary lipemia.
نویسندگان
چکیده
Dietary studies have established a connection between plasma lipoproteins and coagulation factor VII. The present study was undertaken to specifically examine whether factor VII is activated during alimentary lipemia and to investigate the relations of factor VII mass and activity state with fasting and postprandial lipoproteins and free fatty acids (FFAs). Factor VII levels were therefore determined in plasma samples taken before and after intake of a standardized, oral fat load of a mixed-meal type in 33 men (mean age +/- SD, 48.8 +/- 3.2 years) with a previous myocardial infarction at a young age and 10 healthy, age-matched control subjects. A panel of methods for factor VII determination was used to ensure that changes in all potentially existing forms of the factor during alimentary lipemia would be included. Substantial activation of factor VII was found to occur during alimentary lipemia, whereas the number of factor VII molecules remained constant or even appeared to decrease after the test meal. Activation of factor VII was more pronounced in control subjects than patients, and the proportion of activated factor VII molecules was higher in control subjects. Interestingly, factor VII activation, which correlated quantitatively with the degree of postprandial triglyceridemia, seemed to be related to FFA production during lipolysis of triglyceride-rich lipoproteins that were generated in response to fat intake. Postheparin plasma lipoprotein lipase activity was lower in patients, which could offer one explanation why factor VII activity was lower during alimentary lipemia in these subjects despite their exaggerated postprandial triglyceridemia. Thus, activation of coagulation factor VII during alimentary lipemia may result in a procoagulant state that is likely to promote the formation of a coronary thrombus in individuals with established coronary artery disease.
منابع مشابه
Alimentary lipemia and the coagulability of blood: analysis by thrombelastography and silicone clotting time.
THE effect of alimentary lipemia on coagulation has been a matter of controversy for most of the past decade. Reports have confirmed and denied an acceleration of whole blood coagulation.'-'0 A considerable amount of evidence is growing that purports to show lipemia as a factor in the pathogenesis of thrombotic disease, and perhaps even a factor in the genesis of atheroselerosis.1' These specul...
متن کاملAlimentary Lipemia and the Coagulability of Blood
THE effect of alimentary lipemia on coagulation has been a matter of controversy for most of the past decade. Reports have confirmed and denied an acceleration of whole blood coagulation.'-'0 A considerable amount of evidence is growing that purports to show lipemia as a factor in the pathogenesis of thrombotic disease, and perhaps even a factor in the genesis of atheroselerosis.1' These specul...
متن کاملActivation of factor VII during alimentary lipemia occurs in healthy adults and patients with congenital factor XII or factor XI deficiency, but not in patients with factor IX deficiency.
Factor VII activity (FVIIc), a risk marker for coronary heart disease, is increased during postprandial lipemia. Factor VII activation accompanies lipolysis of triglyceride-rich lipoproteins, but the nature of this association and whether it is causal remain uncertain. To explore this issue, four patients with homozygous factor XII deficiency, four with complete factor XI deficiency, six with f...
متن کاملمقایسه اثـر دو رژیـم هورمـون درمانی در زنان منـوپوز بر لیپیدها و فعالیت فاکتورهای انعقادی فیبرینـوژن، VII، VIII و IX
Background: During extrinsic coagulation pathway, a complex is developed between factor VII, calcium and tissue factor (a cell membrane lipoprotein that is exposed after cell injury). Factor VII needs calcium and vitamin K for its biologic activation. Coronary artery disease can be induced by increased level and activity of the coagulation factors VII, VIII and IX. In postmenopausal period, est...
متن کاملFunctional and Molecular Characterization of C91S Mutation in the Second Epidermal Growth Factor-like Domain of Factor VII
Background: Coagulation Factor VII is a vitamin K-dependent serine protease which has a pivotal role in the initiation of the coagulation cascade. The congenital Factor VII deficiency is a recessive hemorrhagic disorder that occurs due to mutations of F7 gene. In the present study C91S (p.C91S) substitution was detected in a patient with FVII deficiency. This mutation has not b...
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ورودعنوان ژورنال:
- Arteriosclerosis and thrombosis : a journal of vascular biology
دوره 14 1 شماره
صفحات -
تاریخ انتشار 1994